This big-cap pharma is a safe bet for next-generation cancer treatments


Oncology is the largest therapeutic area in the biopharma industry in terms of sales. The rapid rise in recent years of drugs to treat diabetes and manage weight loss may have disrupted traditional rankings, but it’s safe to say that oncology will remain one of the most lucrative fields.

ImmunityBio (NASDAQ: IBRX ) There is a mid-cap pharmaceutical manufacturer that is making waves in this space right now; The company’s shares have risen over the past 12 months. Although ImmunityBio looks promising, investors who are betting on the cancer treatment for the long term should pick a bigger, safer stock.

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One that investors should consider today Merk (NYSE: MRK ). Here is Roland.

Doctor and patient in hospital room.
Image source: Getty Images.

ImmunityBio developed a drug called Anktiva, which, in 2024, won approval in the United States to attack bladder cancer. Anktiva made a lot of progress last year. For 2025, ImmunityBio reported total revenue of $113 million, which is about 668% more than last year.

To be fair, since Antiva was only approved in April 2024 (and launched later), it only spent half of that year on the market. So the sales growth compared to 2025, when it was on the market for a whole year, is not completely apples to apples.

Antiva obviously has a lot of momentum, and Immune Bio doesn’t think it’s going to stop. The company is preparing to launch in other regions, including the European Union and Saudi Arabia. In addition, the biotech company plans to expand certain labels for the drug. Anktiva is under clinical trials in lung cancer, lymphoma, ovarian cancer, and other conditions such as HIV infection.

While ImmunityBio is performing well right now, value may be a concern. The company’s market cap is $9.7 billion — with sales of less than $500 million last year. True, the market is remarkable. Even so, there is considerable risk and uncertainty.

Inactiva can fail in intermediate stage or basic studies; Commercial rollouts in other countries can be problematic. And immune bios may face regulatory hurdles. If any of these things happen, the company’s shares will fall, perhaps significantly. Therefore, despite Inactiva’s strong move, Immunity shares look risky.

What about Merck? The company may not grow its sales by 700% year over year, but it generates steady revenue and income. Merck’s most important product is Keytruda, which is the best-selling cancer drug in the world (and second best-selling overall). Keytruda is approved in many different cancers; It has won more than 30 awards in the United States alone. It is impressive.

It is true that Keytruda will lose its patent rights until 2028. However, Merck has planned for this eventuality. The company has received approval for the sub-structure of its crown jewel, which is easier and faster to handle than the original version. This new formula will not lose its patent feature anytime soon, and given its significant benefits, it should attract many patients who might otherwise choose the older version.

So, Merck’s cancer franchise should remain a growth driver over the next decade. At the same time, the company must launch new products, including oncology; Merck is running more than four dozen clinical trials in this area alone. Some are for already approved products seeking label expansion. Most of them are for new cancer treatments.

Merck is going after attractive markets. Its pipeline includes a specific antibody, a new class of drugs that could take over much of the oncology market over the next decade. The company is a great bet on the future of this space.

But Merck’s lineup and pipeline also extends beyond that. In recent years, the company has won approval for drugs that already help meaningfully, such as Venavir, which treats pulmonary arterial hypertension. And it has pipeline candidates in other regions as well. The drug leader’s broad and diverse pipeline and consistent financial results make it a safer bet than ImmunityBio.

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Prosper Junior Bakiny has no position in any of the listed stocks. The Motley Fool has posts on and offers Merck. Motley Fool has a disclosure policy.

Forget Immune Bio: This Big Cap Pharma Is a Safe Play for Next-Gen Cancer Treatments Originally Posted by The Motley Fool

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